Mechanism of Hypotensive Action of Reserpine, an Alkaloid of Rauwolfia serpentina
نویسندگان
چکیده
منابع مشابه
Cytotoxicity of the indole alkaloid reserpine from Rauwolfia serpentina against drug-resistant tumor cells.
BACKGROUND The antihypertensive reserpine is an indole alkaloid from Rauwolfia serpentina and exerts also profound activity against cancer cells in vitro and in vivo. The present investigation was undertaken to investigate possible modes of action to explain its activity toward drug-resistant tumor cells. MATERIAL AND METHODS Sensitive and drug-resistant tumor cell lines overexpressing P-glyc...
متن کاملA Priliminary Note on the Pharmacological Study on Reserpine a New Alkaloid Isolated from Rauwolfia Serpentina
Rauwolfia serpentina, Benth, commonly known as Insanity herb has been used for a long time in Ayurvedic System of Indian Medicine. It has been highly advocated as a general sedative in sleeplessness, anxiety neurosia and hysteria and in the treatment of epilepsy, maniacal and acute insanity. Siddiqui & Siddiqui (19321935) studied the chemistry of some of the active principles extracted from the...
متن کاملHypotensive Action of Reserpine
The effects of large doses of reserpine have been compared in hypertensive and norrmotensive patients. The falls of blood pressure are larger in the hvpertensives than in the normotensives. In normotensive animals small falls of blood pressure occur. Evidence is presented which suggests that the fall of blood pressure in animals is in part mediated through the sympathetic nervous system. There ...
متن کاملAction of reserpine-free extract of Rauwolfia serpentina on hypophysis-adrenocortical axis in rat.
(Abstract only) These results show that the alkaloid complex used here (Reserpine free alkaloids of Rauwolfia serpentina) modifies the response of the body to general stress. Thymus atrophy, adrenal enlargement and gastrointestinal ulcers have been described as the triad of ‘alarm reaction’ by SELYE who has also shown that adrenal enlargement due to stress occurs only in the presence of adenoph...
متن کاملEffect of reserpine-free extract of Rauwolfia serpentina on stress-induced activation of adrenal cortex.
Previous observations on rats have shown that reserpine free extract of R. Serpentina prevents the stress induced activation of adrenal cortex. The therapeutic success of R. Serpentina in clinical hypertension has stimulated extensive research recently. It has been observed that the drug has, in addition to the well marked hypotensive action, a tranquillising influence on the patient. Results o...
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ژورنال
عنوان ژورنال: Nature
سال: 1954
ISSN: 0028-0836,1476-4687
DOI: 10.1038/1741015b0